The following organizations are members of the South Dakota Cancer Coalition:
- AARP
- Active Generations
- American Cancer Society
- American Cancer Society Cancer Action Network (ACS CAN)
- American Childhood Cancer Organization
- American Indian Cancer Foundation
- American Liver Foundation
- American Lung Association
- Assertio
- AstraZeneca
- Avera Cancer Institute
- Avera Health
- Black Hills Center for American Indian Health
- Black Hills Special Services Cooperative
- Blood Cancer United
- Cheyenne River Breast & Cervical Cancer Early Detection Program
- Community HealthCare Association of the Dakotas (CHAD)
- Coteau des Prairies Health Care Systems
- CVS Health
- Delta Dental
- Exact Sciences
- Falls Community Health
- Falls Dental
- Foundation Medicine
- FoY Foundation Inc.
- Genentech
- Gilead Sciences
- Great Plains Breast & Cervical Cancer Early Detection Program/Honor Every Woman Program
- Great Plains Quality Innovation Network
- Great Plains Tribal Health
- HealthPOINT
- Helpline Center
- Horizon Healthcare
- Hurdle Life Coach Foundation
- Huron Clinic
- Immunize South Dakota
- Indian Health Service
- Janssen
- Johnson & Johnson
- KXLG Radio
- Lewis Drug
- Merck
- Mobridge Regional Hospital & Clinics
- Monument Health
- Monument Health Cancer Care Institute
- Pfizer
- Pioneer Memorial Hospital
- Rapid